As the researchers describe in a paper in Cell Metabolism, the drug rapamycin restores leptin sensitivity to diet-induced ...

Chronic pain affects millions of people, but if you're a woman, you're more likely to suffer. This reality has puzzled ...

Since the discovery in 1994 of the obesity gene and its product, the fat-busting protein leptin, scientists have been racing to understand and apply this modern marvel. The ob gene -- ob for obesity - ...

Friedman’s laboratory at the Rockefeller University cloned the leptin gene in 1994. “Before our research, the cause of obesity in diet-induced obese mice was unknown, leaving a critical gap in our ...

Abstract and Introduction Research Design and Methods Results Discussion References Finally, accelerated diabetes occurred in leptin-treated female mice only when leptin administration was started ...

As the researchers describe in a new paper in Cell Metabolism, the drug rapamycin restores leptin sensitivity to diet-induced obese mice, leading to significant loss of fat with only minimal ...

In this study we investigated the physiological effects of elevated leptin in lean mice during discrete developmental time periods on subsequent body weight. Male and female mice that were exposed ...

while female mice still developed normal pain sensitivity. When they analyzed fluid from the spinal cord, they found that ...

Leptin, the satiety hormone produced by fat, affects neuronal signaling in the mouse brain; interference with this pathway can influence the rewarding effects of running in the animals. “Based on ...

As the only child of a self-employed and largely self-taught Canadian radio-and-refrigeration repairman, I spent much of my childhood investigating how things worked by taking them apart.

Using a mouse model of the disease, May-yun Wang et al. 1 tested the effects of treating diabetes with another hormone, leptin. Leptin is secreted by fat cells and is known for modulating energy ...