The research reveals how a drug-like chemical stimulates the action of the lecithin:cholesterol acyltransferase (LCAT) enzyme. It also suggests that future drugs using the same mechanism could be ...

The research reveals how a drug-like chemical stimulates the action of the lecithin:cholesterol acyltransferase (LCAT) enzyme. It also suggests that future drugs using the same mechanism could be ...

Despite over 60 years of research into the biochemistry of LCAT, the enzyme has remained structurally uncharacterized. Although predicted to contain a core α/β-hydrolase fold 13,14, LPLA2 and ...

LYON, France — Researchers have, for the first time, successfully replaced the enzyme found in familial lecithin cholesterol acyltransferase (LCAT) deficiency using recombinant human LCAT ACP ...

"By knowing the architecture of these key enzymes, we can further understand how more than 55 known mutations of LCAT lead to dysfunction and disease," said study senior author John Tesmer ...

Lecithin-cholesterol acyltransferase (LCAT), an enzyme in the bloodstream, is a key component in the reverse cholesterol transport (RCT) system, which is thought to play a major role in driving the ...

Chen. Through proteomics analysis, the research team screened and identified the hepatic factor LCAT, the liver-bone axis regulator. As a cholesterol transferring enzyme, LCAT is able to transfer ...

Scientists have determined the structure of the activated form of an enzyme that helps to return excess cholesterol to the liver. Scientists have determined the structure of the activated form of ...

"By knowing the architecture of these key enzymes, we can further understand how more than 55 known mutations of LCAT lead to dysfunction and disease," said study senior author John Tesmer, a research ...

LCAT, an enzyme in the bloodstream, is a key component in the reverse cholesterol transport (RCT) system, which is thought to play a major role in driving the removal of cholesterol from the body ...

The research reveals how a drug-like chemical stimulates the action of the lecithin:cholesterol acyltransferase (LCAT) enzyme. It also suggests that future drugs using the same mechanism could be used ...