Still, “collectively, these data suggest that inhibition of KCNJ2 can effectively reduce the acute TDP-43 injury and degenerative responses following TBI in vitro and in vivo,” the researchers ...

The finding that mutations in the KCNJ2 gene cause Andersen's syndrome has prompted Ptacek and his colleagues to begin to use family studies and mouse models to trace how the mutation produces ...

Blocking both KCNJ2 gene activity and its protein, respectively, raised the neurons’ survival rate in organoids. The team saw similar effects in mouse models of traumatic brain injury when they ...

The screening came back with a hit—KCNJ2, a gene that encodes a mechanosensory potassium ion channel protein on cell surfaces. “If we suppressed the gene, ...

The next step was figuring out if there is a gene that can rescue this TDP-43 dysregulation. Testing every gene in the human genome, the team found that suppressing KCNJ2 – a gene encoding the cell ...

Shift of gene expression due to inversion of large genome segments In these mouse embryos, a specific probe was used to label all cells, in which the genes Sox9 and Kcnj2 were active at the time of ...

KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury. Cell Stem Cell , 2024; 31 (4): 519 DOI: 10.1016/j.stem.2024.03.004 Cite This Page : ...

They also added DNA for another ion channel, KCNJ2, ... In addition to its cardiac program, Sana has cell and gene therapy programs in diabetes, blood disorders, immunotherapy and other areas.

One of them contains the SOX9 gene and its regulatory elements; the other contains two genes, KCNJ2 and KCNJ16, two potassium channels, and their regulatory elements. Various types of duplications.