More recently, the intracellular signaling enzyme c-jun N-terminal kinase (JNK) emerged as a key promoter of cell suicide. Research into the seemingly opposing roles of these proteins' respective ...

Crosstalk with the Jun N-terminal kinase (JNK), p53 and nuclear-receptor pathways ... The canonical pathway is induced by tumour necrosis factor-α (TNFα), interleukin-1 (IL-1) and many other ...

Mechanistically, the essential role of JNK in hepatocarcinogenesis has been partially explained via its activation through phosphorylation of c-Jun. As a well characterized oncogene, c-Jun is ...