Jamie-Lynn Sigler had just started filming “The Sopranos” at 20 years old when she noticed numbness and tingling in her feet, as well as problems with bladder control, that worsened over time.

In an exclusive clip from their new podcast, MeSsy, Sigler credits Applegate with being "honest and open and vulnerable in a way that took me 22 years to get to" Jamie-Lynn Sigler has been living ...