The affected islets also showed upregulated expression ... with or without T2D helped inform our understanding of islet pathology in T2D. The study confirmed that levels of β-cells were decreased ...

In mice that had been genetically engineered to develop autoimmune diabetes, “killer” T-cells (darker spots) infiltrate and destroy insulin-producing cells in the pancreas (left). Treatment ...

One professor of oncology and pathology at Hopkins, Bert Vogelstein, has said that if he can find a donor who will support the project, he and his team will do their best to sequence the islet ...

of islet amyloid polypeptides (IAPPs) may contribute to the onset of type 2 diabetes mellitus. These results are presented in the February 2010 issue of The American Journal of Pathology.

[25]) Whether the presence of macrophages is causative to type 2 diabetes islet pathology requires further investigation. Hess et al. [26] have shown that bone marrow cells promote islet ...