Matrix 2 (M2) is a helical proton channel that regulates influenza’s internal pH as it passes through different host membranes. The Orthomyxoviridae family classifies four major types of influenza ...

Two surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA), and the M2 ion-channel protein are embedded in the viral envelope, which is derived from the host's plasma membrane.

The influenza M2 viroporin is already a clinically approved antiviral drug target. In other coronaviruses, the E protein viroporin which is involved in growth, could be a potential target for COVID-19 ...

Influenza has historically been an uncommon illness in the newborn period, although epidemic outbreaks in neonatal intensive care units have been described. There is currently significant concern ...