Using next-generation screening and Sanger sequencing, the authors identified six novel IL2RG mutations in a Chinese cohort of nine X-SCID patients. Of the nine patients, two adolescent patients ...

This model was generated by backcrossing an IL2rg (common gamma) knockout model to a RAG2 (recombinase activating gene) knockout model. The resulting mouse lacks various cytokines including IL-2, IL-4 ...