The systemic disease of which AIP is a part has been called IgG4-related systemic diseases ... but AIP can present in more subtle ways without classical symptoms. There is often a dramatic ...

Anti-C1q antibodies are highly prevalent among patients with IgG4-RD, particularly those with renal and skin manifestations.

The study, published in the New England Journal of Medicine, found that treatment with inebilizumab greatly reduced the symptoms of immunoglobulin G4–related disease (IgG4-RD), compared to placebo.