Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while ...

11 To Chen’s excitement, cGAS experiments produced similar results to MAVS; knockdown of cGAS inhibited IRF3 and IFN-β induction, while overexpression ramped up IRF3 and IFN-β production through STING ...

STING and IRF3 can detect DNA outside of these compartments, and report it to the neighboring immune cells by secondary ...