The IGF system is a key modulator of somatic fetal growth. Studies with human fetal tissues have shown a specific spatial and temporal pattern of expression of IGF and IGF binding protein (IGFBP ...

IGF-1 is a small peptide that circulates in plasma with the majority (98%) bound to the IGF-binding proteins (IGFBP). There are six binding proteins, each with a different affinity for IGF-1.

IGF-1 and IGFBP-3 are involved in longevity and could be beneficial to cognition, especially in Alzheimer's disease where experimental studies have shown that IGF-1 opposes the main pathological ...

In the current study, the researchers analyzed levels of IGF-1, IGFBP-1, IGFBP-2, and IGFBP-3 in blood taken from 742 women in the Nurses' Health Study (v) who years later developed type 2 ...

Randomly inherited genetic variations that alter levels of IGF-1 and IGFBP-3 mimic the effect of a randomised trial and are unaffected by the disease process, so the researchers were able to use ...

Specifically, they analyzed 265 SNPs linked to blood levels of IGF-1, and four SNPs for insulin-like growth factor binding protein 3 (IGFBP-3), which binds most of the IGF-1 found in the blood.

IGF-1 and IGFBP-3 are involved in longevity and could be beneficial to cognition, especially in Alzheimer's disease where experimental studies have shown that IGF-1 opposes the main pathological ...

15023 Background: High serum concentrations of insulin-like growth factor-1 (IGF-1) are associated with chemo-resistance in colorectal cancer, whereas IGF binding protein-3 (IGFBP-3) seems to exert a ...