"The research identified this gene as a central regulator of a type of inflammatory cell called the macrophage, which is the main inflammatory cell in all these processes." "IBD usually develops ...

What's more, they found that this enhancer was only active in immune cells known as macrophages – a key immune cell in IBD – and it boosted the gene ETS2. Higher ETS2 activity reflected higher ...

Dr. James Lee is a Clinician Scientist Group Leader at the Francis Crick Institute (London, UK) and an Honorary Consultant ...

Within this desert, the team identified a section of DNA important to macrophages—immune cells that normally protect us from germs but can also drive the inflammation found in IBD patients.

Dr. Lee was the lead author of a landmark 2024 Nature paper that identified ETS2 as a master regulator of inflammatory responses in IBD, and uncovered a novel genetic mechanism behind the disease ...

Researchers discovered that this particular enhancer was only active in macrophages, which are a type of immune cell known to be important in IBD, and boosted a gene called ETS2, with higher ...