A research group has identified the so-called PNOC/NPY nerve cells in the brains of mice. When activated, these cells ...

Leptin isn’t found in food, since it’s produced by the human body. However, eating a diet that is rich in fiber and low in ...

Disruptions in hypothalamic–gonadal and other endocrine axes due to energy deficits are associated with low levels of the adipocyte-secreted hormone leptin and may result in hypothalamic amenorrhea.

Amgen (Thousand Oaks, Calif.) provided recombinant methionyl human leptin (recombinant leptin). Although Amgen provided the recombinant leptin, the data were held by the academic investigators.

If these findings are replicated in future studies, then the evidence indicates that leptin is important to human brain development, too. This study is not the first time connections have been ...

Leptin gene mutations are now treated by administration of the recombinant form of human leptin, metreleptin, in subcutaneous form. This is followed by weight loss, normalization or significant ...

Furthermore, leptin directly stimulates expression of CRP in human primary hepatocytes in vitro. Together, these findings suggest that CRP is not only a marker for obesity-related comorbidities ...

Ozempic, known generically as semaglutide, mimics a different appetite-regulating hormone than leptin, targeting a similar region of the central brain to inhibit cravings, but with greater success.

OBJECTIVE: The pharmacokinetic characteristics of human leptin were examined in rhesus monkeys and in C57BL/6J mice fed a normal chow or a high-fat diet. MEASUREMENTS: Plasma leptin concentrations ...

Earlier this morning (May 2), Oramed (ORMP) announced that the Company is developing a new drug candidate, a weight loss treatment in the form of an oral leptin capsule. Leptin, commonly known as ...

These fly Domeless receptors are very similar to those found in mammals -- so similar that they can be activated by human leptin. This fact led to the subsequent discovery of unpaired 1 ...

Leptin, a pluripotent adipokine, has been discovered as a hormone controlling energy balance in hypothalamic neuroendocrine centers. In addition, recent studies provided ample evidence that leptin ...