Out of these observations was born the 'histone code hypothesis', which states that "distinct histone modifications, on one or more N-terminal tails, act sequentially or in combination to form a ...

The histone-code hypothesis proposes that histone modifications at gene loci are key to their transcriptional activation or silencing during cell differentiation and that histone-methylation marks ...

Emory University. "Scientists take a step towards uncovering the histone code." ScienceDaily. ScienceDaily, 21 December 2009. <www.sciencedaily.com / releases / 2009 / 12 / 091220143925.htm>.

Clinical Implications of Basic Research The Histone Code and Treatments for Acute Myeloid Leukemia Authors: Lucy A. Godley, M.D., Ph.D., and Michelle M. Le Beau, Ph.D. Author Info & Affiliations ...

The work has led Allis and colleagues to propose a “histone code” for gene regulation. One specific chemical change, methylation of the amino acid lysine 4 (K4) on the tail of histone H3, has ...

The histone code hypothesis posits that distinct combinations of histone modifications can recruit chromatin-modifying enzymes and exert epigenetic control over heterochromatin assembly. In the March ...

Review Article Published: July 2010 Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers Ping Chi, C. David Allis & Gang Greg Wang Nature Reviews Cancer 10 ...

The research, which appears June 1, 2013, in the journal Genes and Development, is the latest of many studies to investigate the histone code hypothesized more than ten years ago by Strahl and his ...

5-Prime | The Histone Code Courtesy of IMP/TKadletz What is the histone code? Different chemical marks, such as acetylation, methylation, or phosphorylation, are made to numerous residues on the ...

A first of its kind tool to study the histone code University of North Carolina scientists have created a new research tool, based on the fruit fly, to help crack the histone code.

Cite this: Breaking the Histone Code With Quantitative Mass Spectrometry - Medscape - Oct 01, 2011.

Rockefeller University. "Misreading Of Histone Code Linked To Human Cancer." ScienceDaily. ScienceDaily, 11 June 2009. <www.sciencedaily.com / releases / 2009 / 06 / 090606110445.htm>.