These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

with the levels of histone acetylation, which unwinds DNA and allows transcription to occur. When the researchers probed the specific pattern of histone methylation at human cryptic sites, they found ...

which paralleled acetylation of K9 and K14, while transcriptionally inactive chromatin was associated with K9 methylation. While this study supports the existence of gene regulation by a histone ...

For instance, histone acetylation reduces the positive charge of the histone proteins, thereby reducing their affinity for DNA and causing the chromatin to open (Figure 2). This in turn permits ...

Examples include DNA methylation and histone acetylation, which can turn genes on or off. Despite their differences, both mechanisms contribute to molecular aging. Researchers have long speculated ...