The DNA strand passes through the center of the ring. The researchers discovered that two of the helicase protein parts move along the strand while the other four tether it to the DNA, allowing ...

Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...

A key player on this stage is an enzyme called a helicase. Its job is to unwind the tightly coiled chain of nucleic acids – the DNA or RNA molecule that spells out the organism’s genetic code ...

Two of the FA proteins, BRIP1 (also known as FANCJ) and FANCM contain conserved helicase motifs and can translocate on DNA in an ATP-dependent fashion 5. However, specific roles for these and ...

Intriguing evidence for yet another role of DDX3X has emerged, this time in the context of the DNA damage response. Disruption of this helicase impairs DNA repair pathways, leading to an accumulation ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen interacting with DNA, the laboratories of KAUST Assistant Professor Alfredo De Biasio ...

Published online on Aug. 10 in Nucleic Acids Research, the paper focuses on the DNA damage response pathway and demonstrates how this pathway can reduce the function of a viral enzyme, a helicase, ...

The DNA double helix is made from two strands that run in opposite directions. Each strand is made of a series of bases, A, T, C and G, that pair up between the strands: A to T and C to G. The first ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen interacting with DNA, the laboratories of KAUST Assistant Professor Alfredo De Biasio ...

“The structure shows that the six subunits form a near-planar ring that interacts with the origin, so that each subunit makes unique contacts with the DNA.” The helicase’s domain channel ...