Learn about celiac disease causes, symptoms, diagnosis, and gluten-free treatment options in this easy-to-understand guide.

Having certain gene markers, namely HLA-DQ2 or HLA-DQ8, can also increase your risk of developing the condition. “Nearly all people with coeliac disease have either the HLA-DQ2 or HLA-DQ8 gene ...

TPM502 achieved significant and dose-dependent reduction in IL-2 and IFN-γ release by gluten-specific T cells and durable ...

Most patients with celiac disease are HLA-DQ2(+), with the remaining few expressing HLA-DQ8. These two class II molecules present gluten peptides to the gluten-specific T cells found only in the ...

namely HLA-DQ2 and/or -DQ8. Serological screening for CD should be performed in all T1DM patients in order to allow for early diagnosis of gluten-sensitive enteropathy and so to avoid ...

Topas Therapeutics today announced that it will present clinical Phase 2a data on its lead candidate, TPM502, in celiac disease patients at the upcoming Digestive Disease Week® (DDW) 2025, held from ...

The multi-center, double-blind, randomized, placebo-controlled Phase 2a study evaluated TPM502 in HLA-DQ2.5 positive adults with confirmed CeD on a gluten-free diet (NCT05660109). HLA-DQ2.5 is a ...