Patients with juvenile idiopathic arthritis (JIA) who carried the HLA-B27 genetic marker tended to have worse long-term outcomes, including lower rates of drug-free remission, in a prospective ...

Although HLA-B27-positive uveitis is the most common form of intraocular inflammation, there is no established therapeutic strategy to prevent recurrence. Before TNF inhibitors became available ...

Human leukocyte antigen B27 (HLA-B27) positivity was associated with higher odds of non-remission in patients with juvenile idiopathic arthritis (JIA) at 18 years after disease onset, with men ...

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We think this is a highly genetic-driven disease, with the primary gene involved at this time, we know is HLA-B27. HLA-B27 codes for a protein that is on the surface of inflammation, blood cells.

People who develop uveitis and those with AS often share a genetic marker called HLA-B27. These genetic markers may interact in ways that lead to inflammation in different areas of the body.