Formation of the NK-cell immunological synapse involves several distinct stages, ... (HPS2) both affect the normal formation of lytic granules and lead to the presence of 'giant' lytic granules.

While the new finding significantly advances the understanding of the basic biology underlying m6A and stress granule formation, it may also be relevant to neurodegenerative diseases. “Maybe the ...

Researchers analyzed the inhibition of stress granules formation in cells infected by the human common cold coronavirus HCOV-OC43 and SARS-CoV-2.

More information: Yassine El Bakkouri et al, ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule ...

Finally, cells with enhanced stress granule formation (ddx6 knockout cells) show an increased propensity to exit the cell cycle. These results suggest that stress granules are important regulators of ...

Scientists found that stabilizing stress granules suppresses the effects of ALS-causing mutations, correcting previous models that imply stress granules promote amyloid formation.

Viral invasion – Various viral infections can prompt stress granule formation, suggesting a possible link between certain illnesses and increased Alzheimer’s risk.

Somasekharan, S.P., et al. YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1. J. Cell Biol , March 2015 DOI: 10.1083/jcb.201411047 ...

Interestingly, the PR100 granules contained more of two ALS-related proteins, ataxin-1 and TDP-43, than the arsenite-induced granules did. Next, the researchers asked whether the mechanism of ...

Researchers at Weill Cornell Medicine have illuminated one of the important ways that cells respond to stress. The findings could also be relevant to Alzheimer’s, ALS and other diseases in which this ...