Could the low-carb, high-fat diet be helpful in treating the symptoms of gout? A new study investigates how the diet affects rodents and humans. ... which in turn inhibited the NLRP3 inflammasome.

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Reports , 2017; 18 (9): 2077 DOI: 10.1016/j.celrep.2017.02.004 Cite This Page : ...

The year before, Martinon and Tschopp had shown that inflammation in gout is caused by monosodium urate and calcium pyrophosphate dihydratecrystals that activate the NLRP3 inflammasome.

Nonpharmacologic aspects of gout flare prophylaxis being investigated include the anti-inflammatory effects of omega-3 fatty acids (which act in part by suppression of activation of the NLRP3 ...

In gout, a buildup of urate crystals in joints causes painful inflammation, ... But another of its functions is playing a role in regulating the NLRP3 inflammasome ...

Some studies suggest that the keto diet can reduce joint inflammation caused by gout, ... In 2017, researchers at Yale University looked at how ketosis affects NLRP3 inflammasome, ...

The cause of gout is the accumulation of urate crystals in joints, which continuously reactivate the immune system, leading to activation of the most common type of immune cell in the blood, ...