Complex regions of the human genome remained uncharted, even after researchers sequenced the genome in its entirety. That is, ...

A global team mapped over 100,000 structural variants in human genomes by applying Oxford Nanopore long-read sequencing and a ...

April 14, 2025 – Genome Research (https://genome.org) publishes a second special issue highlighting advances in long-read sequencing applications in biology and medicine.

News Topics OMICs Long-Read Nanopore Sequencing Improves Rare Disease Diagnosis January 26, 2025 Whole genome sequencing (WGS) is not necessarily a solution for someone with a rare, monogenic disease.

The cause of rare diseases is increasingly being detected through genome sequencing, which involves reading the entire human DNA by first breaking it into small pieces—short reads. Christian ...

As a graduate student in Howard Chang ’s group at Stanford University, Yost and her colleagues addressed this shortcoming by leveraging The Cancer Genome Atlas (TCGA) and high-throughput ...

In ExIGS, expansion microscopy is integrated with in situ genome sequencing to simultaneously sequence genomic DNA and image nuclear proteins at nanoscale resolution within single cells.