GJB2 mutations often lead to fragmentation of gap junctions and gap junction plaques (GJPs) which are composed of CX26. While the inheritance of a recessive GJB2 mutation containing two copies of ...

GJB2 is the gene responsible for approximately half of all cases of hereditary hearing loss. Connexin 26 (CX26), which is encoded by GJB2, helps in the formation of intercellular gap junctions ...

GJB2 is the gene responsible for approximately half of all cases of hereditary hearing loss. Connexin 26 (CX26), which is encoded by GJB2, helps in the formation of intercellular gap junctions ...

Scientists from Juntendo University and The University of Tokyo have created an adeno-associated virus (AAV)-based genome editing approach to treat genetic hearing loss caused by the GJB2 R75W ...

SENS-501 (OTOF-GT) currently being developed in a Phase 1/2 clinical trial, targets deafness caused by mutations of the gene encoding for otoferlin and GJB2-GT targets hearing loss related to ...

Get Instant Summarized Text (Gist) A novel adeno-associated virus (AAV) vector-mediated genome editing approach has been developed to repair the R75W mutation in the GJB2 gene, which causes ...