GDF-15 secretion by the tumor has been shown to prevent T cell migration into the tumor and suppresses T cell function and the adaptive immune response in the tumor microenvironment.

More information: Ignacio Melero et al, Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours, Nature (2024). DOI: 10.1038/s41586-024-08305-z ...

GDF-15 secretion by the tumor has been shown to prevent T cell migration into the tumor and suppresses T cell function and the adaptive immune response in the tumor microenvironment.

GDF-15 is primarily known for its function in feto-maternal tolerance, an immunosuppressive mechanism that protects the fetus from the mother’s immune system.

GDF-15 is chiefly known for its function in feto-maternal tolerance – an immunosuppressive system that protects the foetus from a mother’s immune system. Researchers highlighted that GDF-15 blocks LFA ...

The researchers found that serum GDF-15 levels were significantly increased in patients with CAD versus the healthy group (P < 0.001). There was a positive correlation between GDF-15 and Gensini ...