Fatty acid synthase (FASN), an enzyme that drives de novo lipogenesis, plays a relevant role in metabolic disorders such as obesity, non-alcoholic fatty liver disease (NAFLD) or type 2 diabetes.

and fatty acids is coupled to the generation of an electrochemical gradient across the inner mitochondrial membrane, which is harnessed by the ATP synthase to drive the formation of ATP.

which is an essential fatty acid as it cannot be synthesized de novo in animals. The primary precursor is obtained from the diet in the form of linoleic acid. The two COX enzymes have different ...