Four years ago, protein drug developer Zymogenetics in Seattle began developing a recombinant version of the blood-clotting protein thrombin ... stock fell $2 on approval.

T = tissue, F = factor, a = activated. Reproduced from reference 8, with permission. Interactions of anticoagulants with thrombin. Panel A shows heparin bound to thrombin at exosite 2 and to ...

thrombin and factor Xa (FXa). The recent approval of dabigatran etexilate for the prevention of venous thromboembolic events in patients who have undergone total hip- or knee-replacement surgery ...