In order to analyse the molecular mechanisms of Taxol-induced cytotoxicity, we studied the involvement of mitogen-activated protein kinases (MAPK) ERK and p38 as well as the p53 pathways in Taxol ...

Moreover, to determine whether the expression of some apoptosis-related proteins is regulated by the ERK/p38 MAPK pathway. Cell viability was measured using a 3-(4,5-dimethylthiazol-2-yl)-2 ...

In particular, the new study reveals HERC1 ligase is able to regulate the activation of ERK and p38 kinase through the union of ubiquitin molecules with the C-RAF factor. According to the authors ...

By contrast, EKAREN5, a FRET-based ERK sensor, showed no CDK2 crosstalk. A related p38 KTR is also partly affected by CDK2 activity. To address this, we developed linear and non-linear computational ...

The results indicated that biglycan and decorin activate the ERK and p38 MAPK signaling pathways, which are vital for bone remodeling and homeostasis. This study not only clarifies the distinct ...

These included MEK1 and MEK2, which control a pathway called ERK involved in cellular division and survival, and MEK3 and MEK6, which regulate the p38 pathway that's involved in stress-induced ...

“Lethal toxin (LT), the major virulence factor of B. anthracis, proteolytically inactivates MEKs and disables downstream ERK, p38, and JNK pathway signaling leading to tissue damage and ...

The results indicated that biglycan and decorin activate the ERK and p38 MAPK signaling pathways, which are vital for bone remodeling and homeostasis. This study not only clarifies the distinct ...

The team found that resistance to this drug is associated with the hyperactivation of the cellular pathways PI3K/AKT and MEK/ERK and have explored the possibility of inhibiting these pathways as a ...

These included MEK1 and MEK2, which control a pathway called ERK involved in cellular division and survival, and MEK3 and MEK6, which regulate the p38 pathway that’s involved in stress-induced ...