Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway.

Impairment of Src/ERK signalling could be the basis for clinical ... It also raises the possibility of creating pathway-specific agonists for the GHR and related class 1 cytokine receptors.

of the agonist, neurotensin (PolyPeptide, France). Many different parameters can be identified when using this HTRF p-ERK assay, from the preparation of working cells through to cell lysis ...

About KGF alternative peptide (FGFR2b agonist) [Product code ... We confirmed that the KGF alternative peptide activates ERK (upper left figure) and exhibits proliferation activity (upper right ...

One-fifth of patients in a phase 1 study responded to an investigational ERK inhibitor from Merck, bolstering hopes that this type of drug could be used effectively in combination with other ...

We investigated whether a novel, synthetic, peptide-based erythropoietin-receptor agonist (Hematide, Affymax) can stimulate erythropoiesis in patients with anemia that is caused by ...