One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids—key components ...

This organelle is called the endosome. If the pathways by which this sorting occurs fails at any stage, several diseases such as neurodegenerative diseases and certain cancers can occur.

From the endosome, the substance is either recycled back to the cell membrane (for exiting the cell) or forwarded to a lysosome -- a cell organelle containing enzymes for the breakdown of ...

Multiple Paths to the Endosome APP (red) and BACE1 (pink) follow distinct routes to the early endosome. Blocking specific points along the ARF6-mediated BACE internalization pathway has opposing ...

In two recent Cell Reports papers, scientists led by Scott Small, Columbia University, New York, detail new insights into the function of the retromer, an endosome protein complex linked to ...

A study led by Daniel Jane-Wit, MD, Ph.D., a Yale School of Medicine associate professor of medicine (cardiology) and of immunobiology, could revolutionize our understanding of immune signaling ...