Extracellular signal-regulated kinase 5 (ERK5), a distinct member of the mitogen-activated protein kinase (MAPK) family, is increasingly recognised for its central role in transducing ...

"Since ERK5 inhibition potentiates the efficacy of chemotherapy in animal models, we believe that ERK5 could be an effective target to tackle endometrial cancer", says Dr. Lizcano.

Cancer Research Technology Ltd. has disclosed proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety covalently bonded to a mitogen-activated protein kinase 7 (MAPK7 ...