Together, these studies uncover novel compensatory pathways that may be involved in tumor adaptation to inhibition of the KRAS–RAF–MEK–ERK pathway. Key among these is the activation of ...

The team found that resistance to this drug is associated with the hyperactivation of the cellular pathways PI3K/AKT and MEK/ERK and have explored the possibility of inhibiting these pathways as a ...

It achieves this by dysregulating crucial signaling pathways, including TGF-β, PI3K/AKT/mTOR, Wnt/β-catenin, Hippo/YAP, ...