E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

In a pioneering collaboration with AbbVie, Northwestern researchers have discovered a new way to potentially treat cancer by ...

We have selected the protein group of RING type ubiquitin E3 ligases to assign them in plant developmental stages and organs by gene expression profiles, by high throughput phenotyping of ...

Investigators found that an E3 ligase FBXO22 could effectively mediate ... will continue to explore the use of TPD in different types of cancer. "We can use this method to continue to discover ...

However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.

Professor Zoran Rankovic’s group is developing PROTACs, Molecular Glue Degraders, and E3 ubiquitin ligase chemical probes to study cancer biology and develop novel cancer drugs. Our group's research ...

Researchers from the Bhogaraju Group at EMBL Grenoble have developed a new method to study a critical type of protein ... a group of enzymes called E3 ubiquitin ligases attach a small protein ...