G1 (gap1) is a growth phase that occurs before ... First, they bind to different members of the E2F family in vivo. Second, these associations occur at distinct stages of the cell cycle: whereas ...

It emerges that cells in a ‘primed’ G1 state — characterized by intermediate activation of a transcription factor called E2F — can hold off making this commitment or even reverse back into G1.

Neuroblastoma is a pediatric solid tumor characterized by dysregulation of the CDK-RB-E2F axis, leading to elevated E2F activity, uncontrolled progression through the G1/S transition and an aggressive ...

To see the cell-cycle progression, they fused GFP to the degron of E2F and mRFP (red fluorescent protein) to the degron of Cyclin B, which is degraded in the same manner as Geminin. Using these ...

Therefore, in the presence of cyclin D, transcription factor E2F can transcribe proteins involved in progression into S phase, including the G1/S phase cyclins E and A. Another example of a target ...

A new research paper titled "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex" has been published in ...

Capsaicin induces G1/S cell cycle arrest leading to apoptosis of multiple myeloma cells through suppression of STAT3 activation and STAT3-regulated gene products ...

The vector is transcriptionally regulated by the E2F promoter that is up-regulated in retinoblastoma (Rb) pathway-defective tumor cells, common in most IR-NMIBC bladder tumors. Additionally, the virus ...

“Our study enables us to envisage a global picture of genes and pathways dysregulated during senescence and provides novel evidence for involvement of p53/p16/RB-E2F-DREAM repressional targets ...