Doxazosin remains a commonly used antihypertensive ... 0.05-0.2 mg/day; or clonidine, 0.1-0.3 mg twice daily) or an open-label step 3 agent (hydralazine, 25-100 mg twice daily) could be added.

Twenty-five percent of the patients randomized to doxazosin and 14% of those randomized to chlorthalidone were not on their assigned medication at the time of the interim analysis. Will the ...