The reconstructed vesicle cycle model provides critical insights into synaptic transmission, advancing neuroscience and potential therapeutic applications.

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles.

Another study, led by 2013 Nobel Laureate Thomas Südhof at Stanford University in California, found that α-synuclein multimerizes upon binding to membranes, and recruits protein complexes called ...

At any given time, only a few synaptic vesicles are in "docked" position, meaning loaded and ready to release neurotransmitter. Immediately after an action potential, the number of docked vesicles ...

The paper S.S.H. Wang et al., “Fusion competent synaptic vesicles persist upon active zone disruption and loss of vesicle docking,” Neuron, 91:777-91, 2016. Hair trigger Neurons send each other ...

At any given time, only a few synaptic vesicles are in "docked" position, meaning loaded and ready to release neurotransmitter. Immediately after an action potential, the number of docked vesicles ...

The authors observed similar losses in neurons cultured from the knockout mice. In contrast, the numbers of docked vesicles-those poised for fusion and release-were similar in knockouts and controls.

Video depiction of vesicle fusion and tethering. In the active zone in the central left of the video, docked vesicles (dark blue) fuse with the membrane, releasing their contents and being quickly ...