However, the enzyme we have studied (known as PfA-M1), which is essential for parasite viability, is located outside the digestive vacuole meaning that it is easier to target from a drug perspective." ...

Cell Death & Disease - Drug-induced permeabilization of parasite's digestive vacuole is a key trigger of programmed cell death in Plasmodium falciparum. Skip to main content.

The endosome-apical vacuole interaction resembled pexophagy in yeast cells, by which peroxisomes are internalised by digestive vacuoles in response to the nutritional conditions 18.

If there is an alternative way to increase the permeability of the digestive vacuole, it could make the digestive vacuole more accessible to those drugs again." Kuan-Yi Lu, First Author.

(Medical Xpress)—One of the world's most devastating diseases is malaria, responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman ...

The antimalarial drugs CQ and PPQ work by entering the parasite's digestive vacuole (a compartment resembling a stomach) and altering it so that the parasite poisons itself on its own toxic waste ...

In the 1950s, earlier Nobel winner Christian de Duve identified small structures inside cells that carried lots of digestive enzymes. ... One exception to that is the vacuole, ...

The malaria gene pfcrt may be a "master" gene that controls the parasite's resistance to a variety of antimalarial drugs, according to new research by Stephen Ward and colleagues.

PolyMedix’s defensin-mimetics target the digestive vacuole of the parasite that causes malaria, Plasmodium falciparum, via a mechanism distinct from other anti-malarial agents, essentially ...