Courtesy of Roger J. Pomerantz and the Center for Human Virology and Biodefense ©2003 John Wiley & Sons, Ltd. Dicer cleaves exogenous or endogenous double-stranded RNA (dsRNA) into 21–25-nucleotide ...
Dicer also processes long dsRNA molecules into small interfering RNA (siRNA) duplexes. Only one strand of the miRNA:miRNA* duplex or the siRNA duplex is preferentially assembled into the RNA ...
Viroid replication generates dsRNA intermediates, which are processed by Dicer into 21- to 25-nucleotide siRNAs. These siRNAs are then incorporated into siRNA – ribonuclease complexes (RISC). If the ...
siRNAs are 21-25 nucleotide dsRNA molecules that are perfectly complementary to their ... long primary miRNAs (pri-miRNAs), which are processed by the enzymes Drosha and Dicer to generate mature ...
RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA vaccines and double-stranded RNA (dsRNA) therapies. But while health ...
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