so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA ...

To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic acid hybridization to fish out specific DNA sequences along with the bound proteins. By using enzymes ...

Histones proteins were selected early in evolution to transform DNA into chromatin filaments formed by many nucleosomes. The ...

Chromatin remodelers play a key role in regulating access to DNA (which is packed within the cell into chromatin), hence allowing other DNA-interacting processes to take place. Although mutations ...

As our bodies grow, cells proliferate to form tissues, and cells frequently have to be repaired or replaced throughout life..

Scientists at Sanford Burnham Prebys and collaborators across the country published findings March 5, 2025, in Nature ...

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But as they age, they accumulate more and more DNA damage. Until now, it has ...

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

Ultraviolet (UV) radiation from the sun is a well-known cause of DNA damage, which can lead to diseases like skin cancer. But ...

We are interested in understanding the mechanisms governing interactions between proteins that are important for regulating transcription and the sites to which they bind in DNA and chromatin. Our ...