DNA polymerase is responsible for the process of DNA replication, during which a double-stranded DNA molecule is copied into two identical DNA molecules. Scientists have taken advantage of the ...

Many DNA polymerases also have ... polymerase and exonuclease active sites might effectively inhibit DNA synthesis and the repair of nucleotide analogues and DNA damage by alkylating agents. Two ...

A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...

The team initially set out to study another replication machinery protein, single-stranded DNA-binding protein, and its interaction with DNA polymerase. However, they first needed to establish how the ...

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

Since PCR's advent, scientists have developed filters to manage predictable stutter, but it remains a point of frustration while interpreting DNA ... the polymerase’s binding to its template strand.