Internucleosomal DNA cleavage yields a ladder pattern in electrophoretic gel, which is a biochemical hallmark of apoptosis (see part b of the figure for an image of a DNA electrophoretic gel with ...
Activation of caspase 3 and PARP cleavage, by western blot and immunohistochemistry, and DNA fragmentation, by gel electrophoresis and TUNEL, are frequently used as apoptosis assays in vivo.
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