As the DNA concentration in the sensing region increases, the rate of change of the output voltage increases too, and the ...

About 20% of bowel cancers, known as mismatch repair deficient (MMRd) cancers, are caused by mutations in DNA repair genes. But disrupting these repair mechanisms is not entirely beneficial to tumors.

Cryptic mtDNA mutation is a predominant form of mutation and reaches physiologically relevant levels in later life. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-57286-8 ...

DNA tilts and stretches underlie differences in mutation rates across genomes Date: August 3, 2023 Source: Baylor College of Medicine Summary: Researchers have changed the way to look at DNA. They ...

The DNA mutations that drive evolution are generally thought to be fairly random, but a new study suggests there’s some order to the chaos. Comparing the genomes of hundreds of plants grown in a ...

DNA's 3D shape — its twisted ladders complexly curled into coils and loops — and other features beyond its genetic code may influence where "hotspots" of cancer-causing mutations accumulate.

Mutations cause major changes to an organism only when they occur in genes — sections of DNA that code for a particular protein. Most of the human genome is made of non-gene DNA, Monroe said.

Researchers have found that DNA mutations are not random. This changes our understanding of evolution and could one day help researchers breed better crops or even help humans fight cancer.

The difference was about “fitty,” as in an average of 50 differences in the 2022 DNA compared to 2018-2019 DNA. That’s about six to 12 times more than what would have been expected over that ...

Journal reference: Cobo, I., et al. (2022) DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages.