This narrated animation illustrates the process of protein synthesis, starting with chromosomal DNA inside the cell's nucleus. A gene is transcribed into messenger RNA, which leaves the nucleus ...

It has been previously found that non-coding or repetitive patterns of DNA – which make up around half of our genome – could disrupt the replication of the genome.

The mechanism reveals that damages to non-coding DNA, which are often hidden, accumulate more in slowly proliferating tissues, such as those of the liver or kidneys. Unlike in organs that ...

Corces and his colleagues identified a gene important for Drosophila development — modifier of mdg1 or mod (mdg1) — that produces two transcripts, one from each DNA strand. Exons I to IV are ...

Then they induced a single, 12-base strand of DNA from the human p53 gene to build a complementary copy of itself out of the modified nucleotides.

DNA double-strand breaks (DSBs) can trigger the production of short non-coding RNAs (ncRNAs) at the site of the DNA lesion. a | In Neurospora crassa, DNA damage induces the production of qiRNAs ...

This article reviews several proposed mechanisms of molecular evolution operating in non-coding regions of the chloroplast genome and argues that awareness and identification of these mechanisms are ...

The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for DDR activation. Here we show ...

Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. Explore new technology used in the St. Jude-led discovery.

Sorting through non-coding DNA to find the root of chemotherapy resistance "The non-coding 98% of the genome contains instructions," said co-first author Jackson Mobley, PhD, St. Jude Department ...