(A) Relative urinary cystine concentration of Slc3a1 KO and WT mice from both sexes. (B) Typical hexagonal cystine crystals from the urine of Slc3a1 KO and WT mice. Scale bar,100 μm. (C ...

It involves the regulation of the cystine/glutamate transport system xc−, with glutathione (GSH) and glutathione peroxidase 4 (GPX4) preventing toxic lipid peroxide accumulation. Ferroptosis ...