The researchers were able to describe the cellular signalling path which causes uncontrolled growth when the Cyld gene is defective. Furthermore, there is evidence that such a defective Cyld gene ...

2003; Kovalenko et al., 2003; Trompouki et al., 2003). CYLD was originally identified as a gene mutated in familial cylindromatosis (FC), a genetic condition that predisposes patients for the ...

The condition is intimately linked with mutations in the CYLD gene, a critical tumour suppressor whose deubiquitinating function regulates key cellular pathways. Research in this area has provided ...

Missense mutations in the CYLD gene are present in individuals with syndromes such as multiple familial trichoepithelioma (MFT), but the pathogenic roles of these mutations remain unclear.

Missense mutations in the CYLD gene are present in individuals with syndromes such as multiple familial trichoepithelioma (MFT), but the pathogenic roles of these mutations remain unclear.

The discovery of the gene, known as CYLD, was made possible through information made publicly available by the Human Genome Project at the Wellcome Trust's Sanger Centre. Professor Stratton, who now ...

To narrow in on the gene involved, researchers performed whole-exome sequencing on five family members. In the region of interest they found a single variant in the CYLD gene that always segregated ...