We developed a cell division–activated Cre-lox system for stochastic recombination of loxP-flanked loci in mice. Cre activation by frameshift reversion is modulated by DNA mismatch-repair status ...

Site-specific recombination tools such as the Cre–loxP system are used to create animal models where conditional gene deletion/activation studies are required. In the current proof of principle ...

A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." ...

Cre-loxP, a system commonly wielded to manipulate gene expression in mammals, may not be the right fit. In their editorial paper published in Oncoscience, researchers Piotr Czarnota and Jaroslaw ...

Cre-Controlled CRISPR, the new method developed by a team of Dresden researchers led by Prof. Michael Brand, combines the benefits of the Cre/lox system with the CRISPR/Cas9 genetic scissors.

Despite the emergence of new gene targeting technologies like CRISPR/Cas9, the Cre-Lox system in mouse models remains unparalleled in its efficiency, precision, and broad applicability in ...

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese ...

A new method should allow precise manipulation of large sections of DNA. As proof, the researchers produced ...

We spoke to Stefan Momma, Group Leader, University Hospital Frankfurt, at Extracellular Vesicles 2016.

However, its broader application has been hindered by three critical limitations: (1) reversible recombination reactions—stemming from the inherent symmetry of Lox sites—can negate desired edits; (2) ...