Cre-loxP, a system commonly wielded to manipulate gene expression in mammals, may not be the right fit. In their editorial paper published in Oncoscience, researchers Piotr Czarnota and Jaroslaw ...

On November 14, 2023, a new editorial was published in Oncoscience, entitled, “Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research.” ...

A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." ...

The Cre-Lox system is commonly used for this purpose. In this strategy, recombinase loxP sites are engineered into a gene sequence of interest.

Cre- loxP recombination allows scientists to excise, insert, or invert specific DNA segments with unprecedented accuracy. 1,2 This works through two key components: a Cre recombinase and loxP sequence ...

Dr. Moreno’s lab is part of the Children's Nutrition Research Center which houses laboratories of varied disciplines, a vast array of state-of-the-art equipment, a greenhouse, observation labs and ...