Mitosis is truly a molecular spectacle, ... condensin (Hirano, 2002; Hagstrom & Meyer, 2003). Like cohesin, condensin is an elongated complex of several proteins that binds and encircles DNA.

Condensin is required for the substantial reorganization of chromosome structure as chromosomes compact during mitosis . Condensin components were identified in screens for chromosome-segregation ...

As cells enter mitosis, however, a condensin machine also begins extruding loops. When a condensin machine inevitably runs into a cohesin machine, the condensin machine removes the cohesin machine ...

Their models determined that in the lead-up to mitosis, a ring-shaped protein molecule called condensin II, composed of two connected motors, lands on the DNA. Each of its motors move in opposite ...

Andreas Brunner et al, Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis, Journal of Cell Biology (2024). DOI: 10.1083/jcb.202405169 Provided by ...

“If condensin I was prematurely activated before the entry into mitosis, for instance, it could damage DNA or cause chromosomes to become unstable, potentially producing cancer cells.” In previous ...

Removing condensin disrupted the elongated shape of chromosomes in ... These observations support a model where a global reduction of chromatin acetylation during mitosis establishes an ...

In fact, mutations in condensin structure can result in severe chromosome segregation defects and lead to cell death, cancer formation, or rare developmental disorders called ‘condensinopathies'.

The team also performed condensin-depletion experiments to investigate the constraining process during mitosis. They found that depleting condensins caused abnormal chromosome shapes and increased ...

During mitosis, DNA undergoes significant compaction to form chromosomes. A large protein ring complex called condensin plays a key role in the compaction process.

Their models determined that in the lead-up to mitosis, a ring-shaped protein molecule called condensin II, composed of two connected motors, lands on the DNA.