STAG2 protein mutations and associated spatial alteration of DNA structure can contribute to development of leukemia
It helps to properly fold the DNA and thus regulate gene activity. Cohesin contains two very similar subunits, STAG1 or STAG2 ...
Queen Mary University of London5y
Deciphering the mechanism through which mutations in BRD4 cause neurodevelopmental disorder
The majority of neurodevelopmental disorder risk genes including BRD4 and cohesin subunits associate with enhancers, suggesting enhancer dysfunction could be a major cause of neurodevelopmental ...