The separase cuts the cohesin rings, which hold the sister chromatids together. These then migrate to the opposite poles of the spindle apparatus. Disclaimer: AAAS and EurekAlert! are not ...

Cohesin contains two very similar subunits, STAG1 or STAG2. In myeloid leukemias, mutations in the cohesin subunit STAG2 are particularly common, while those in STAG1 are almost never observed.

In human chromosomes, cohesin is always protected in the same region, but in the nematode worm C elegans, chromosomes have to figure it out from scratch every time they divide. They somehow ...