The cofilin pathway is composed of a group of kinases and phosphatases that regulate cofilin and coordinately initiate actin polymerization and cell motility in response to stimuli in the ...

Using a mouse model for early-stage tauopathy, Dr. Kang and his colleagues showed that Aβ-activated cofilin promotes tauopathy by displacing the tau molecules directly binding to microtubules ...

Cofilin is part of the actin-depolymerizing factor/cofilin (ADF/cofilin) family, is present in all eukaryotes. In mammals, there are two major isoforms: cofilin 1, found mainly in non-muscle ...

Sybille M. Eibert, Kyeong-Hee Lee, , Urban Sester, Guido H. Wabnitz, Thomas Giese, Stefan C. Meuer, Yvonne Samstag, Stuart F. Schlossman, Cofilin Peptide Homologs Interfere with Immunological Synapse ...

Since cofilin activation is largely regulated by SSH1, an enzyme also activated by Aβ, the researchers propose that inhibiting SSH1 represents a new target for treating Alzheimer's disease or ...