The CYP2D6 polymorphisms that cause some ultra-rapid codeine metabolism are among the SNPs detected. However, these kits don't detect all of the possible contributions to being an ultra-rapid ...

The liver converts codeine into morphine using the enzyme CYP2D6, a process that causes pain relief in most people. However, genetic differences in some people cause either too much or too little ...

Analogous to codeine and dihydrocodeine, the production of the active metabolite hydromorphone from hydrocodone is reduced in CYP2D6 PMs. [34]In vitro studies revealed that the O -demethylation of ...

Concomitant use or discontinuation of CYP2D6 inhibitors, CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments (see full labeling). Withdraw gradually (esp. if opioid ...

Codeine is a widely used analgesic drug, and the O -demethylation of codeine into morphine is mediated by the genetically polymorphic enzyme cytochrome P4502D6. The CYP2D6 gene duplication leads ...

This trait stems from a variation in an enzyme — cytochrome P450 isoenzyme 2D6 (CYP2D6) — that converts codeine into morphine and tramadol into a metabolite called O-desmethyltramadol (M1).

1. Crews, KR, Gaedigk, A, Dunnenberger, HM, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.

CYP2D6 is the key enzyme responsible for the generation of the potent tamoxifen metabolite, endoxifen. Multiple studies have examined the relationship of CYP2D6 status to breast cancer outcomes in ...